Renal Denervation in Hypertension

Inclusion Criteria: * Individual is more than 18 and less than 75 years old at time of randomization * Essential hypertension diagnosed during a complete work-up within the past 2 years * Office blood pressure ≥140 and/or 90 mmHg despite a stable medication regimen including full tolerated doses of 3 or more anti-hypertensive medications of different classes, including a diuretic * 2 functional kidneys sizing ≥ 90 mm; eGFR ≥ 40 mL/min/1.73m² (MDRD formula) * Suitable renal anatomy compatible with the endovascular denervation procedure * Signed Informed consent * Confirmed resistant hypertension defined by diurnal ambulatory blood pressure measurement ≥ 135 and/or 85 mmHg after 4 week standardized triple antihypertensive treatment Exclusion Criteria: * Patients with an estimated glomerular filtration rate (eGFR) of less than 40 mL/min/1.73 m2 * Patients with secondary hypertension * Kaliemia ≥ 6mmol/L * Patient with single functioning kidney * Patient with contrast media allergy * Patient with any implantable device incompatible with radiofrequency energy delivery * Patient with contra-indication to the anti-hypertensive standardized medication regimen * Patient with transient or fixed cerebral ischemia within 3 months before inclusion * Patient with myocardial infarction, unstable angina pectoris, coronary bypass or percutaneous angioplasty within 3 months before inclusion * Patient with type 1 diabetes mellitus * Patient with malignancy within the 5 past years * Patient with atrial fibrillation and/or a brachial circumference of ≥ 42cm