Ozurdex for Treatment of Recalcitrant Diabetic Macular Edema

Inclusion Criteria: * Presence of NPDR or PDR as confirmed by fluorescein angiography * Prior treatment with \>= 2 intravitreal anti-VEGF injections but no treatment in last 4 weeks * \< 0.1 LogOCT decrease in macular edema on high resolution OCT between initial visit and following treatment with \>= 2 intravitreal anti-VEGF injections * Age 18 years or older * ETDRS Visual acuity between 3 and 78 letters (approximate Snellen equivalent of 20/25 to 20/800) * Ability to provide written informed consent * Capable of complying with study protocol. Exclusion Criteria: * Intraocular injection of steroid medication within prior 3 months * Evidence of significant geographic atrophy on fluorescein angiography in the opinion of the treating physician * Concurrent ocular disease (wet AMD, significant ERM, etc) that would limit visual acuity in the opinion of the treating physician * Prior vitrectomy surgery * Use of systemic steroids (eg, oral, intravenous, intramuscular, epidural, rectal, or extensive dermal) within 1 month prior to day 1. * Known history of IOP elevation in response to steroid treatment in either eye that resulted in any of the following: a) = 10 mm Hg increase in IOP in response to steroid injection, or b) IOP = 25 mm Hg and required 2 or more anti-glaucoma medications to keep IOP below 21 mm Hg. * Patients who are pregnant. * Unwilling or unable to follow or comply with all study related procedures