Effects of Phlebotomy on Insulin Sensitivity in Insulin Resistance-associated Hepatic Iron Overload Patients

Inclusion Criteria: * Age between 18 and 70 years * Ferritin between 450 and 1000 µg/L * Hepatic iron overload proved by MRI (CHF \>36 µmol/g) * Body mass index \> 25 kg/m² * Fasting glycemia \<1,26 g/L * HbA1c \< 6,5% * Signed written and informed consent Exclusion Criteria: * Other causes of hyperferritinemia: * Inflammatory syndrome (CRP \>10 mg/L) or inflammatory, immune or malignant diseases * Hyperferritinemia-cataract syndrome (familial cataract or personal history of cataract before 50 years old) * Low ceruloplasmin level * Porphyria (cutaneous signs) * Haemochromatosis established by the genotype (C282Y homozygous or C282Y/H63D coumpound heterozygous genotypes) * Contraindication of phlebotomy * Haemoglobin \<13,5 g/dL (threshold established by the Etablissement Français du Sang) * Heart failure or coronary heart diseases * Hepatic failure, renal (GFR \<50mL/min) or respiratory insufficiency (chronic dyspnea) * Poor venous system * Viral, immune, genetic, vascular, malignant or toxic chronic hepatic disease * Alcohol consumption more than 21 doses per week during 5 years or more * Type 1 or type 2 diabetes * Oral anti-diabetic, corticoids or immune suppressor drugs * Hepatic severe disease * Claustrophobia, having a pace-maker or intracerebral clips * Subjects deprived of their liberty by judicial or administrative decision, subjects that are not affiliated to social security or topics exclusion period of a previous study