PCT and Clinical Algorithm for Determination of Duration of Antibiotics

Inclusion Criteria: * Adult patients (19 years and older) treated with ABx for reasons other than prophylaxis within the last 24 hours and who are admitted to a critical care environment. Exclusion Criteria: * Declined consent * Any infection that according to evidence-based guidelines which would usually receive more than 2 weeks of antibiotic therapy including, but not limited to; * Infective endocarditis * Osteomyelitis * Undrained abscess * Not expected to survive 48 hours * Immunosuppression (HIV positive, any immunosuppressive medications, any steroid dose, neutrophil count less than 1.0) * Previously enrolled in this study * Presently enrolled in a separate study which is felt by study investigators to have biological or clinical process in conflict with this study.