Microvascular Function Assessment in Healthy Subjects

University Hospital, Angers16 enrolled

Overview

Current stimulation induces microvascular dilation in human skin. The investigators aimed to study (1) whether the current vasodilation is amplified after two segmental current stimulation as compared to one stimulation; (2) whether this amplification relies on prostaglandin-sensitive mechanisms. A double-blind randomized placebo-controlled crossover trial is conducted in Angers, France.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Physiology of Microvascular Skin

Interventions

acetylsalicilic acids (Aspirin)DRUG

single oral dose of 1g.

PlaceboDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> or equal to 18 years old * Healthy subjects Exclusion Criteria: * Aspirin allergy

Locations (1)

University Hospital

Angers, Maine et Loire, France

Outcomes

Primary Outcomes

The increase of Laser Doppler Blood Flow after the second current stimulation

Time frame: 1 hour

Secondary Outcomes

The increase of Laser Doppler Blood Flow after the second current stimulation after aspirin administration

Time frame: 1 hour

Data from ClinicalTrials.gov

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