A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. RhinoChill (iCOOL 1)

Inclusion Criteria: * Sedation, intubation and mechanical ventilation * Combined ICP-temperature-probe * Indication to lower body temperature * Age ≥ 18 years Exclusion Criteria: * Body weight \> 120 kg * Fever \> 38.5°C * Chronic sinusitis * Current or past fracture or surgery of the paranasal sinuses * Severe infection with bacteremia or sepsis ≤ 72 h * Severe renal insufficiency * Severe liver insufficiency * Acute pulmonary embolism * Acute myocardial infarction * Severe cardiac insufficiency (NYHA ≥ III) * Threatening ventricular dysrhythmia * Cardiac dysrhythmia with bradycardia (heart rate \< 50 /min, QTc \> 450 ms, sick sinus syndrome, AV-block II-III°). * Known hematologic disease with increased risk of thrombosis (e.g. cryoglobulinemia, cold agglutinins, sickle cell anemia) * Known vasospastic vascular disorder (e.g. Raynaud's phenomenon or thromboangiitis obliterans)