Safety and Efficacy of Vilazodone in Major Depressive Disorder

Inclusion Criteria: * Men and women, 18-70 years of age * Currently meet the DSM-IV-TR criteria for Major Depressive Disorder * The patient's current major depressive episode must be at least 8 weeks and no longer than 18 months in duration Exclusion Criteria: * Women who are pregnant, women who will be breastfeeding during the study, and women of childbearing potential who are not practicing a reliable method of birth control * Patients with a history of meeting DSM-IV-TR criteria for: * any manic, hypomanic or mixed episode, including bipolar disorder and substance-induced manic, hypomanic, or mixed episode; * any depressive episode with psychotic or catatonic features; * panic disorder with or without agoraphobia; * obsessive-compulsive disorder; * Schizophrenia, schizoaffective, or other psychotic disorder; * bulimia or anorexia nervosa; * presence of borderline personality disorder or antisocial personality disorder; h. mental retardation, dementia, amnesia, or other cognitive disorders * Patients who are considered a suicide risk