Surgery Combined With rAd-p53 Gene in Treatment Advanced Non-small-cell Carcinoma

Inclusion Criteria: * historically diagnosed advanced non-small lung cancer * has surgery indication * age 18 years old or greater * life expectancy greater than 12 weeks * ECOG: 0-2 * no prior chemotherapy, radiotherapy in 2 weeks * Neutrophils≥1.5×10\^9/L,platelet≥80×10\^9/L, Hb≥≥80g/L,bilirubin≤1.5×2mg/dl, ALT and AST≤2×institutional upper limit of normal,Cr≤1.5×institutional upper limit of normal,coagulation tests(INR and PTT)within normal range * subject provides signed informed consent Exclusion Criteria: * hypersensitive to study drug * with a coagulational test unnormal or a bleeding disorder * infections * with serious condition which can't stand a surgery * pregnant or lactating * principle investigator consider not suitable