Citalopram vs Clomipramine vs Placebo in Recurrent Depression

University of Aarhus59 enrolled

Overview

citalopram and clomipramine are better than placebo in preventing new episodes of depression in patients with recurrent depression

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Depression

Interventions

CitalopramDRUG

ClomipramineDRUG

placeboDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with recurrent depression * Sustained response achieved (3 consecutive monthly ratings at the HDS below 13)after a treatment requiring index episode Exclusion Criteria: * Contraindications to study medications * Pregnancy * Substance abuse

Outcomes

Primary Outcomes

2 Hamilton Depression Rating Scale scores of at least 16 with one weeks interval or initiation of another antidepressant treatment

Time frame: 2 years of follow-up

Secondary Outcomes

Study termination due to adverse event or non-compliance

Time frame: 2 years of follow-up

Data from ClinicalTrials.gov

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