The proposed study will assess the ability of a naturally occurring sugar to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines by establishing a novel, easy to deliver, cost-effective therapy for treating age-associated arterial dysfunction and reducing the risk of cardiovascular disease with age.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
110
100g maltose 1/day
100g 1/day
University of Colorado, Boulder Clinical Translational Research Center
Boulder, Colorado, United States
Arterial Stiffness
Arterial pulse wave velocity
Time frame: 12 weeks
nitric-oxide mediated endothelium-dependent dilation
flow-mediated dilation and forearm blood flow responses to acetylcholine in the presence and absence of N'-monomethyl-L-arginine
Time frame: 12 weeks
Systemic oxidative stress and inflammation
circulating markers of oxidative stress and inflammation
Time frame: 12 weeks
Endothelial cell oxidative stress and inflammation
inflammatory and oxidative stress markers in biopsied vascular and arterial endothelial cells
Time frame: 12 weeks
Insulin sensitivity
intravenous glucose tolerance test
Time frame: 12 weeks
Endothelial cell autophagic flux
Time frame: 12 weeks
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