The purpose of this randomized controlled two-part study examines the effects of a structured sports intervention before, during and after hematopoetic stem cell transplantation (hsct) in children and adolescents. The main aspects in the sports groups are resistance, endurance and flexibility training. The control group performs a mental training as well as relaxation exercises.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
68
Supervised exercise training (aerobic, resistance, flexibility), 5 times per week
Memorial/ mental training and relaxation, 5 times per week
University Children's Hospital
Frankfurt am Main, Hesse, Germany
Muscle strength
Upper limb: hand grip strength with JAMAR dynamometry; Lower limb: maximal isometric voluntary strength of M. quadriceps femoris
Time frame: change between hospital admission and discharge (approximately 4-6 weeks) and 3 months and 6 months after transplantation
Fatigue
Pediatric Quality of Life Inventory (PedsQL)
Time frame: change between hospital admission and discharge (approximately 4-6 weeks) and 3 months and 6 months after transplantation
Biomarker in blood
Hematological and immunological reconstitution
Time frame: daily
Body composition
Bioelectrical Impedance Analyse (BIA; Data Input GmbH)
Time frame: one time per week and change between 3 months and 6 months after transplantation
Endurance performance
6-Minute-Walking-Test (6MWT); Ergospirometry and Echocardiography
Time frame: change between hospital admission and discharge (approximately 4-6 weeks) and 3 months and 6 months after transplantation
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