Total knee and hip arthroplasty for osteoarthritis is performed on still broader indications even in elderly patients with previous or current medical conditions. Especially comorbidity like cardiovascular diseases and conditions with increased risk of bleeding or previous thrombo-embolic events are major challenges. To facilitate safe use of ropivacaine as an analgesic, information on the concentrations levels after autologous blood transfusion following local infiltration analgesia is very crucial. However, very limited data are available. To verify the safety of autologous blood transfusion, ropivacaine concentrations were studied in 52 patients undergoing either total knee arthroplasty or total hip arthroplasty.
Study Type
OBSERVATIONAL
Enrollment
52
Local infiltration analgesia with ropivacaine 3 mg/kg, max 200 mg
Local infiltration analgesia with ropivacaine 3 mg/kg, max 200 mg.
Vendsyssel Hospital, Frederikshavn, Aalborg Hospital, Aarhus University
Aalborg, Denmark
Concentrations of ropivacaine in serum
Concentrations of ropivacaine in serum before and after autologous blood transfusion will be analyzed.
Time frame: 6 hours
Analysis of ECG and pulse rate
ECG, pulse rate and blood pressure will be analyzed in proportion to concentrations of serum before and after autologous blood transfusion
Time frame: 6 hours
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