The purpose of this study is to evaluate if the Synera Patch (lidocaine/tetracaine patch), used to numb the skin before IV placement, is effective in reducing pain associated with propofol IV administration when inducing general anesthesia, compared to Gebauer's Ethyl Chloride topical anesthetic skin refrigerant.
Commonly, anesthesiologists inject Propofol, a sleeping medication, intravenously to induce general anesthesia. Propofol injection is associated with pain that can be severe. The investigators also place a lidocaine/tetracaine skin patch (Synera) to decrease pain associated with IV placement. Because the local anesthetics of the Synera patch diffuse deep underneath the skin, in this study the investigators would like to evaluate whether the application of Synera Patch can decrease the pain associated with propofol injection. Children will be randomized to receive either the patch or the Ethyl Chloride before the IV placement. A total of 33 patients will be enrolled in each group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
80
70 mg lidocaine / 70 mg tetracaine
Spray is to be applied topically to skin (dorsum of the hand for study purposes)until it turns white or for up to 10 seconds.
Memorial Herman Hospital
Houston, Texas, United States
RECRUITINGNumber of children in each group who do not feel pain or have mild pain on propofol injection.
The primary outcome variable is the success/failure of therapy. The therapy is considered a success if a child feels no pain OR has mild pain.
Time frame: Within one hour, plus or minus one half hour
Pain intensity
A blinded independent observer and a blinded anesthesiologist will rate pain on propofol injection according to a pain scale: 1. \- no pain 2. \- mild pain (associated with facial expression of pain) 3. \- moderate pain (pulling/withdrawal of the arm) 4. \- severe pain (screaming)
Time frame: Within one hour, plus or minus one half hour
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