The purpose of this study is to determine whether fish oil supplementation is effective in the treatment of abnormal fat metabolism in subjects with elevated cholesterolaemia.
The use of statin therapy in familial hypercholesterolaemia (FH) is known to reduce cardiovascular risk and is a first line recommendation, however, there is considerable residual risk predicted by the presence of fasting and post-prandial hypertriglyceridaemia. This study will examine the effect of oral n-3 fatty acid ethyl esters supplementation (4g/day, Omacor) on postprandial hypertriglyceridaemia and post-prandial arterial function when administrated to FH patients at increased risk of cardiovascular disease due to their residual fasting hypertriglyceridaemia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
30
4g Omega capsule for 12 weeks
All FH subjects are on standard statin treatment during study period
School of Medicine & Pharmacology,University of Western Australia
Perth, Western Australia, Australia
Postprandial changes in triglyceride-rich lipoprotein concentrations
Incremental area-under-the-curve (AUC) for triglycerides, apoB-48 and retinyl palmitate
Time frame: 12 weeks
Triglyceride-rich lipoprotein kinetics
Kinetic studies of apoB48 and apoB-100 kinetics
Time frame: 12 weeks
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