Current recommendations require a QRS duration of ≥120ms as a condition for prescribing cardiac resynchronization therapy (CRT). This study was designed to test the hypothesis that patients with heart failure of ischemic origin, current indications for defibrillator implantation and QRS \<120ms may benefit from CRT in the presence of marked mechanical dyssynchrony.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
120
Implantation of a CRT defibrillator with a standard right atrial, right ventricular defibrillator and left ventricular leads
Ospedale Santa Maria di Loreto Mare
Naples, Italy
heart failure clinical composite score
Patients are classified according to a score, which assigns subjects to one of three response groups - improved, worsened, or unchanged. Patients are judged to be worsened if they died or were hospitalized because of worsening heart failure (at any time during the 12 months), or demonstrated worsening in NYHA functional class at their 12-month visit. Patients are judged to be improved if they had not worsened and had demonstrated improvement in NYHA functional class at 12 months. Patients who are not worsened or improved are classified as unchanged.
Time frame: 12 months
time to the first heart failure hospitalization or death
Kaplan-Meier analysis is used to analyze time to death or first heart failure hospitalization
Time frame: up to 30 months
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