Immunogenicity and Reactogenicity of PCV13 Among Infants and Children in Burkina Faso

Infants inclusion criteria * Child has birth weight ≥ 2500g * Child was born at ≥ 37 weeks of pregnancy or judged to be full-term by midwife or birth attendant * Mother has resided in Burkina Faso for at least 2 years * Mother has African nationality * Child will reside in Bobo-Dioulasso urban area for the duration of the study * Parent or guardian has given informed consent for child's participation Infants exclusion criteria * Child was born with a congenital abnormality * Child has chronic or acute severe illness requiring specialized medical care * Child has a blood coagulation disorder * Mother has known HIV infection * Child is enrolled in another clinical trial * Child has known allergy to a component of the vaccine * Child received a pneumococcal vaccine outside the context of the trial * Child is 53 days of age or older at 6 week visit * Child weighs \<3500g at the 6 week visit * Blood draw at 6 week visit was unsuccessful after 3 attempts Toddlers inclusion criteria * Child is 12 to 15 months of age * Child has resided in Burkina Faso since birth * Child has African nationality * Child will reside in Bobo-Dioulasso urban area for the duration of the study * Parent or guardian has given informed consent for child's participation Toddlers exclusion criteria * Child has visible signs of severe malnutrition * Child has chronic or acute severe illness requiring specialized medical care * Child has a blood coagulation disorder * Child has known HIV infection * Child is enrolled in another clinical trial * Child has known allergy to a component of the vaccine * Child received a pneumococcal vaccine outside the context of the trial * Child's weight at first vaccination visit is lower than the 5th percentile of Burkinabe children (8.0 to 8.7 kg according to age) * Blood draw at first vaccination visit was unsuccessful after 3 attempts Children inclusion criteria * Child is 2 to 4 years of age * Child has resided in Burkina Faso since birth * Child has African nationality * Child will reside in Bobo-Dioulasso urban area for the duration of the study * Parent or guardian has given informed consent for child's participation Children exclusion criteria * Child has visible signs of severe malnutrition * Child has chronic or acute severe illness requiring specialized medical care * Child has a blood coagulation disorder * Child has known HIV infection * Child is enrolled in another clinical trial * Child has known allergy to a component of the vaccine * Child received a pneumococcal vaccine outside the context of the trial * Child's weight at first vaccination visit is lower than the 5th percentile of Burkinabe children * Blood draw at first vaccination visit was unsuccessful after 3 attempts