Method Study: Bilateral TAP Block With 24 Hours Infusion

Glostrup University Hospital, Copenhagen8 enrolled

Overview

The purpose of this method study in healthy volunteers is to determine the extent of sensory block following Transversus Abdominis Plane (TAP) block with 24 hours infusion of ropivacaine versus infusion of saline. Furthermore, to determined the analgesic effect of the TAP block and the influence on the lung function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Postoperative Pain

Interventions

Infusion of ropivacainePROCEDURE

TAP block with ropivacaine 20 ml 0,5%. Catheter with infusion of ropivacaine 0,2% 5 ml/h 24 hours on one side of the abdomen.

Infusion of salinePROCEDURE

TAP block with ropivacaine 0,5% 20 ml. Catheter with infusion of saline 5 ml/h 24 hours.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age between 18 and 30 years * written consent * ASA 1 * BMI between 18 and 25 * males Exclusion Criteria: * unable to communicate in Danish * relevant drug allergy * alcohol or/and drug abuse * daily intake of prescription pain medication the last 4 weeks * pain medication in the last 48 hours * previously operated abdominal

Locations (2)

HOC, anesthesiology, Rigshospitalet

Copenhagen, Denmark

HovedOrtoCentret, Rigshospitalet

Copenhagen, Denmark

Outcomes

Primary Outcomes

Change in extend of sensory block from baseline (pre block) to 24 hours post block, based on 6 measurements

Extent of sensory block using pinprick and ice