The Effect of Dexmedetomidine in the Management of Pain After Uterine Artery Embolization

Severance Hospital66 enrolled

Overview

The investigators examined the effect of dexmedetomidine in the management of pain after uterine artery embolization.

Leiomyoma are the most common female reproductive tract tumors. Uterine artery embolization(UAE) is a minimally invasive treatment alternative to hysterectomy and myomectomy. However, post-procedural pain control after UAE remains a major problem. Therefore, the aim of study is to evaluate the efficacy of dexmedetomidine in pain control after UAE.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Pain Control

Interventions

DexmedetomidineDRUG

Dexmedetomidine(Dexmedetomidine 2 mL and normal saline 98 mL mixed -\> 2㎍/mL) : the infusion of 0.2㎍/kg/hr is started at 30 minutes before the procedure and the infusion dose is raised to 0.4㎍/kg/hr after completion of procedure

Normal saline 0.9%DRUG

Normal saline 100mL(guess as 2㎍/mL):the infusion of 0.2㎍/kg/hr is started at 30 minutes before the procedure and the infusion dose is raised to 0.4㎍/kg/hr after completion of procedure

Eligibility

Sex: FEMALEMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age ≥ 20, * ASA class I and II Exclusion Criteria: * bradycardia (\< 45 bpm) * heart block * liver failure * renal failure * uncontrolled hypertension * body mass index ≥ 30 kg/m2

Locations (1)

Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine

Seoul, South Korea

Outcomes

Primary Outcomes

Fentanyl consumption by patient-controlled analgesia

Time frame: 24 hours

Secondary Outcomes

Side effects

Time frame: 24 hours

Data from ClinicalTrials.gov

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