Testosterone Pellets Plus Vitamin D and E Versus Vitamin D and E Alone for the Treatment of Peyronie's Disease

Inclusion Criteria: * acquired penile curvature of \> 30 degrees and \< 90 degrees associated with palpable penile plaque on physical examination * onset of curvature within 18 months prior to signing consent form * serum TT \< 500 ng/dl at the screening visit Exclusion Criteria: * prior history of treatment for PD that includes intra-lesional injections, topical creams, or surgery * prior treatment with oral therapy at least 2 weeks prior to signing consent form (e.g. Potaba, Vitamin E, colchicines) will be acceptable for inclusion * prior history of treatment for testosterone deficiency * presence of dense calcified plaque by US or plain radiograph * taking the medication Coumadin * hypersensitivity to testosterone, stearic acid, or polyvinyl pyrolidone (the constituents of Testopel) * unable to achieve adequate erection with penile injection to access degree of curvature * undergone definitive treatment for prostate cancer, bladder cancer, or other pelvic malignancies including surgery, external beam radiation therapy, brachytherapy, cryotherapy. * prior history of prostate cancer, hematologic disorders, chronic liver disease including cirrhosis and hepatitis C, disorders affecting the immune system, including infection with human immunodeficiency virus, or psychiatric disorders including major depression, schizophrenia, bipolar disease * history of cerebrovascular accident, history of deep venous thrombosis within the past 5 years or history of untreated or severe sleep apnea * PSA \> 4.0 ng/dL at the screening visit, unless prostate cancer has been excluded to the investigator's satisfaction * clinically significant abnormal lab results that would put the subject at increased risk or compromise the integrity of the study data, in the opinion of the investigator * received any other investigational drug within 30 days