Salsalate as an Adjunctive Treatment for Patients With Schizophrenia

Inclusion Criteria: * Age 18-65 years; * Diagnosis of schizophrenia or schizoaffective disorder; * Stable dose of the current antipsychotic drug for at least one month; * Well established compliance with outpatient treatment per treating clinician's judgment; * Able to complete the cognitive assessment battery (must be English speaking); * Female subjects will be eligible to participate in the study if they are of non-childbearing potential or of child-bearing potential and willing to practice appropriate birth control methods during the study. Exclusion Criteria: * Inability to provide informed consent; * Current substance abuse; * Psychiatrically unstable per treating clinician's judgment; * Significant medical illnesses including uncontrolled hypertension, diabetes, seizure disorder, severe cardiovascular, cerebrovascular, pulmonary, or thyroid diseases; * Currently on immunosuppressant medication including oral steroids; * Use of anti-coagulants (heparin, LMWH, warfarin, cilostazol, clopidogrel, dabigatran); * History of chronic infection (including, HIV and hepatitis), malignancy, organ transplantation, blood dyscrasia, central nervous system demyelinating disorder, and any other known autoimmune or inflammatory condition; * Experienced asthma, urticaria or allergic type reaction after taking aspirin, salsalate, or other NSAIDS; * Pregnancy or breastfeeding; * Pre-existing chronic tinnitus. * Known hypersensitivity to salsalate.