Observational Study of Complications Related to Use of Peripherally Inserted Central Catheters

Inclusion Criteria: * Male or Female Age \> 18 years requiring central venous access * Ability to comply with study requirements * Written Informed Consent Exclusion Criteria: * Previous enrollment in study * Current or recent upper extremity thrombosis, occlusion or stenosis * Previous axillary lymph node dissection * Skin inflammatory condition or rashes within 15 cm from insertion site * Pre-existing history of hypercoagulability unrelated to malignant disease * Participating in trial involving antithrombotic, anticoagulant or anti- infective drug therapies * Positive blood culture within 48 hours from planned PICC placement * Known, renal insufficiency with chronic creatinine levels \> 1.7 mg/dl