Phase II Intratumoral IL12 Plasmid Electroporation in Cutaneous Lymphoma

Inclusion Criteria 1. Biopsy confirmed mycosis fungoides of stage IB - IIIB; 2. Participants must have failed or have been intolerant to at least one standard of care therapy; 3. Participants must have a minimum of one lesion, or affected area in erythrodermic patients (T4/stage III), that meets all following criteria: * Accessible for pIL-12 electroporation; * Adequate size such that 6-mm biopsy can be collected prior to treatment; 4. Participants must have one additional lesion, or affected area in erythrodermic patients, that remains untreated for the duration of the study; 5. Age ≥ 18 years old; 6. Participants must have Eastern Cooperative Oncology Group (ECOG) performance status 0-2; 7. Required wash out period of 4 weeks from last dose for the following prior therapies: * Topical therapy; * Radiotherapy (including photo therapy); * Multi-agent chemotherapy; * Systemic biological therapy; * Histone deacetylase inhibitors (HDAC) inhibitors; * Interferon alpha and other investigational therapies; 8. For women of childbearing potential, negative pregnancy serum test within 14 days to the first study drug administration, and use of birth control from 30 days prior to the first day study drug administration and 30 days following last day study drug administration; 9. Male participants must be surgically sterile, or must agree to use contraception during the study and at least 30 days following the last day of study drug administration. 10. Life expectancy of at least 6 months; 11. The patient must have adequate renal and hepatic function as assessed by standard laboratory criteria within 4 weeks prior to enrollment: * Creatinine \< 2 x upper limit of normal (ULN); * Serum bilirubin within institutional normal limits; * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \< 1.5 x ULN; * Absolute neutrophil count (ANC) \> 1000/mm; * Platelet count \> 100,000 /mm; 12. Able to give informed consent and able to follow guidelines given in the study. Exclusion Criteria 1. Prior therapy with IL-12 or prior gene therapy; 2. Prior treatment with Campath (alemtuzumab) within 1 year of enrollment; 3. Concurrent immunotherapy, chemotherapy, or radiation therapy for duration of patient participation on study; 4. Concurrent steroid therapy; 5. Concurrent anticoagulant therapy (acetylsalicylic acid \[ASA\]≤ 325mg/day allowed); 6. Evidence of significant active infection (e.g., pneumonia, cellulitis, wound abscess, etc.) at time of study enrollment; 7. Patients with current evidence of large cell transformation (LCT) with aggressive disease at study entry (patients with a history of LCT are eligible if pathologic evidence at study entry indicates there is no presence of LCT); 8. Known history of human immunodeficiency virus (HIV), Human T-cell leukemia virus (HTLV) -1/2 infection, hepatitis B or hepatitis C (active, prior treatment, or both); 9. No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease-free for 2 years; 10. Significant cardiovascular disease (i.e. New York Heart Association \[NYHA\] class 3 congestive heart failure; myocardial infarction within the past 6 months; unstable angina; coronary angioplasty with the past 6 months; uncontrolled atrial or ventricular cardiac arrhythmias); 11. Any other medical history, including laboratory results, deemed by the investigator to be likely to interfere with patient's participation in the study, or to interfere with the interpretation of the results; 12. Participants with electronic pacemakers or defibrillators are excluded from this study as the effect of electroporation on these devices is unknown; 13. Pregnant and breast-feeding women are excluded from the study as effects on the fetus are unknown and there may be a risk of increased fetal wastage.