Intravitreal Aflibercept Injection for Radiation Retinopathy

Inclusion Criteria: * Retinopathy associated with previous I-125 brachytherapy for uveal melanoma (85 Gy over 96 hours) at least 6 months prior to enrollment * Ability to provide written informed consent and comply with study assessments for the full duration of the study * Age \> 18 years * Center involved macular edema \> 300µm in thickness on SD-OCT * Best corrected visual acuity of 20/40- 20/400 * Birth control therapy for females of child-bearing age Exclusion Criteria: * Pre-existing retinopathy due to other disorders * Vision decrease is considered to be due to ischemic radiation retinopathy without macular edema or optic neuropathy * Presence of metastasis * Pregnancy (positive pregnancy test) or lactation * Premenopausal women not using adequate contraception. The following are considered effective means of contraception: surgical sterilization or use of oral contraceptives, barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel, an IUD, or contraceptive hormone implant or patch. * Prior enrollment in any study with intravitreal aflibercept injection * Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated * Uncontrolled glaucoma in the study eye (defined as IOP ≥ 30 mmHg despite treatment with anti-glaucoma medication) * History of cerebral vascular accident, myocardial infarction, transient ischemic attacks within 4 months of study enrollment. * Active infectious conjunctivitis, keratitis, scleritis, or endophthalmitis in either eye * Any concurrent intraocular condition in the study eye (e.g., cataract or diabetic retinopathy) that, in the opinion of the investigator, could either require medical or surgical intervention during the study period to prevent or treat visual loss that might result from that condition, or if allowed to progress untreated, could likely contribute to loss of at least 2 Snellen equivalent lines of BCVA over the 6-month study period * Presence of significant subfoveal fibrosis or atrophy * Intraocular surgery (including cataract surgery) in the study eye within 2 months of enrollment * Active intraocular inflammation (grade trace or above) in the study eye * History of allergy to fluorescein, ICG or iodine, not amenable to treatment * Prior/Concomitant Treatment: * Panretinal photocoagulation treatment * Previous intraocular steroids or PDT within 3 months * Previous participation in any studies of investigational drugs within 30 days preceding Day 0 (excluding vitamins and minerals) * Previous treatment with intravitreally (in either eye) or intravenously administered Avastin (bevacizumab) within 60 days or concomitant use in either eye outside the scope of this study * Previous use of Eylea, Macugen or Lucentis in study eye within 60 days or concomitant use in either eye outside the scope of this study * Prior submacular or vitreous surgery