Comparison of Body Composition & Weight Change in Users of Progestin-only Contraception During the First Year of Use

Washington University School of Medicine345 enrolled

Overview

The purpose of this study is to learn if women gain weight using progestin-only methods of contraception and if so, how much. The investigators will look at users of two progestin-only methods: the levonorgestrel-containing intrauterine contraceptive (LNG-IUC) and the etonorgestrel (ENG) subdermal implant, and compare these users' weight change to that of users of a non-hormonal method, the copper intrauterine device. The primary hypothesis is that ENG implant and LNG-IUC users' weight and body composition will increase more than the copper-IUD users. The investigators will collect body composition data using dual-energy x-ray absorptiometry (DEXA), and collect information about diet and activity using validated questionnaires.

Study Type

OBSERVATIONAL

Enrollment

345

Conditions

Weight Change

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

The study has finished enrolling new participants. Inclusion Criteria: * Participants between the ages of 18 and 45 years * Participants starting the copper IUD or implant through their provider * First study visit must occur within 14 days of method insertion Exclusion Criteria: * DMPA in the past 16 weeks * POPs, LNG-IUC, or the implant in the past 4 weeks * Thyroid disease * Autoimmune disease * Diabetes (excluding gestational) * History of eating disorder * Currently taking antidepressants for \< 6 months * Currently taking antipsychotics * Currently taking oral glucocorticoids (steroids, i.e. prednisone) for more than 6 months * Currently breastfeeding * Less than 6 months post-partum

Locations (1)

Outcomes

Primary Outcomes

Weight

Compare changes in body weight and BMI measurements

Time frame: Baseline and 12 months

Secondary Outcomes

Body composition

Compare parameters including fat mass and percentage and central-to-peripheral fat ratios

Time frame: Baseline and 12 months