Renal Toxicity of Iodixanol and Iopromide in Patients With Renal Dysfunction

Inclusion Criteria: * Provides written Informed Consent and is willing to comply with protocol requirements * Is referred for cardiac angiography, with or without PCI * Has a documented predose serum creatinine level of 1.5～3.5 mg/dl for men and 1.3～3.0 mg/dl for women * Serum creatinine levels of twice tests conform with the baseline criteria, and the difference of twice serum creatinine tests is not more than 30%(first test: within 3 month,prior to enrollment; second test: at enrollment) Exclusion Criteria: * Has a history of hypersensitivity to iodine-containing compounds * Has end-stage renal disease * Has kidney transplantation * Has creatinine clearance rates \>60 ml/min in last 3 months * Has acute coronary syndrome with heart failure(above class II in accordance with Killip or class III in accordance with the classification of the New York Heart Association (NYHA)) and shock * Patients with cancer * Has diabetes with serious complications, other kidney organs * Patients with serious blood system disease * Heart failure \[class III\~Ⅳ in accordance with the classification of the New York Heart Association (NYHA) and (or) pulmonary edema\] * Patients with hepatic insufficiency\[3 times as ALT and (or) AST normal reference value limit\] * Has received an iodinated contrast agent within 14 days prior to the administration of the study agent * Is scheduled to receive an iodinated contrast agent within 7 days after administration of the study agent * Has acute renal failure or end-stage renal disease requiring dialysis in the past 3 months * Use of 3 days continuously nonsteroidal anti-inflammatory drugs within 1 week of the procedure * Patients with hypotension \[(SBP\<80 mmHg for over 1h and needing Medication or intraaortic balloon counterpulsation(IABP) \] * Uncontrolled condition of hyperthyroidism * pregnancy or lactation * Is planned to receive the drugs without permission in this protocol * Participating in another intervention research study in last 3 months * legally incapacitated or limitations * Any other conditions not suitable to be enrollment