Insufficient sleep may be one of the most common, and most preventable, obesity risk factors. The investigators wish to determine whether 14 nights of modest sleep restriction results in increased energy balance, thus potentially increasing the risk of obesity. The investigators hypothesize that sleep restriction will result in increased energy balance.
Numerous studies have reported that self-reported short sleep duration is associated with obesity and weight gain. Insufficient sleep may be one of the most common, and most preventable, obesity risk factors. Given that sleep restriction is largely voluntary and potentially correctable, understanding the mechanisms that link insufficient sleep to positive energy balance and the development of obesity, particularly visceral obesity, is crucial to clinical applications, public health policy, and informing future studies. The investigators wish to determine whether 14 nights of modest sleep restriction results in increased energy balance, thus potentially increasing the risk of obesity. The investigators will combine energy balance, biomarker, and imaging data with state-of-the art sleep monitoring to provide unambiguous data on the effects of sleep restriction on obesity. Together, the investigators findings will help explain whether the reduced sleep duration in the general population may be contributing to the current epidemic of obesity, and suggest strategies to reduce this risk.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
13
14 days of sleep restriction, 4 hours of sleep per day.
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Change in caloric intake and hunger
Change in caloric intake and hunger, measured during acclimation, experimental and recovery timepoints.
Time frame: baseline to 21 days
Change in energy expenditure
Change in energy expenditure, including activity energy expenditure, thermic effect of food (TEF), and basal metabolic rate (BMR), measured during acclimation, experimental and recovery timepoints..
Time frame: baseline to 21 days
Change in fat tissue characteristics and body composition
Changes in fat tissue characteristics from serial fat biopsies, and in body composition from DEXA and CT imaging, measured during acclimation, experimental and recovery timepoints.
Time frame: baseline to 21 days
Change in metabolic hormones
Change in metabolic hormones measured during acclimation, experimental and recovery timepoints.
Time frame: baseline to 21 days
Change in neurocognitive deficits
Change in neurocognitive function measured by battery, measured during acclimation, experimental and recovery timepoints..
Time frame: baseline to 21 days
Change in blood pressure and autonomic function
Change in mean arterial blood pressure and autonomic function, measured during acclimation, experimental and recovery timepoints.
Time frame: baseline to 21 days
Change in markers of inflammation and endothelial function
Change in markers of inflammation and endothelial function, measured during acclimation, experimental and recovery timepoints.
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Time frame: baseline to 21 days
Change in electrocardiographic characteristics
Change in electrocardiographic characteristics, measured during acclimation, experimental and recovery timepoints.
Time frame: baseline to 21 days
Change in arterial stiffness
Change in arterial stiffness, measured during acclimation, experimental, and recovery timepoints.
Time frame: baseline to 21 days
Change in cardiovascular reactivity
Change in cardiovascular reactivity, measured during acclimation, experimental, and recovery timepoints.
Time frame: baseline to 21 days