The purpose of this pilot study is to compare the dynamic response of microcirculation in the skin on the bottom of the big toe after applying controlled plantar stress in 25 diabetic subjects with a history of foot ulcer and 25 age-matched healthy controls to better understand the role of local hypoxia in neuropathic foot ulceration in subjects with diabetes. The investigators hypothesize that if they apply a gait simulating load to the plantar foot and measure microvascular function, diabetic individuals will demonstrate an increased delay in reestablishing microvascular flow compared to healthy individuals.
Study Type
OBSERVATIONAL
Enrollment
18
Temple University School of Podiatric Medicine Gait Study Center
Philadelphia, Pennsylvania, United States
Latency time after occlusive loading
The time between removal of occluding pressure and the initiation of the post-occlusive hyperemic response as measured by laser Doppler.
Time frame: approximately 2.75 minutes after start of collection protocol
Response time to baseline
The time interval between the start of post-occlusive hyperemic response and when the response curve reaches the baseline, or reference, flow level as measured by laser doppler.
Time frame: 2.75 seconds after start of collection protocol
Response time to Maximum Flow
The time interval between the start of the post-occlusive hyperemic response and the time to reach maximum flow as measured by laser doppler
Time frame: At least 2.75 seconds after the start of collection protocol.
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