Microbial Community Transplantation on the Armpit/Foot

University Ghent4 enrolled

Overview

The malodour generation of a person's armpit/foot is caused by the bacteria thriving on that armpit/foot. In order to alter or reduce once bad body odour or foot odour, the living microbial community on the foot/armpit of a non-malodorous person will be transmitted (or up scaled and transmitted) to the foot/armpit of a malodorous person. The odour is evaluated by a trained smelling panel, the bacteria living on the armpit/foot is examined by means of molecular techniques. The microbial transplantation and its follow-up happens under the supervision of a doctor.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Heavy, Bad Body Odour From Armpit Heavy, Bad Body Odour From Foot

Interventions

Microbial transplantBIOLOGICAL

Every subjects has 2 armpits and 2 feet. One armpit/foot is treated, the other is not treated.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Bad armpit or foot odour

Locations (1)

Ghent University

Ghent, Belgium

Outcomes

Primary Outcomes

Change in odour severity after bacterial transplantation

Odour evaluation by a trained smelling panel.

Time frame: Baseline and day 1

Change in odour severity after bacterial transplantation

Odour evaluation by a trained smelling panel.

Time frame: Baseline and day 2

Change in odour severity after bacterial transplantation

Odour evaluation by a trained smelling panel.

Time frame: Baseline and day 3

Change in odour severity after bacterial transplantation

Odour evaluation by a trained smelling panel.

Time frame: Baseline and day 4

Change in odour severity after bacterial transplantation

Odour evaluation by a trained smelling panel.

Time frame: Baseline and day 5

Change in odour severity after bacterial transplantation

Odour evaluation by a trained smelling panel.

Time frame: Baseline and week 2

Change in odour severity after bacterial transplantation

Odour evaluation by a trained smelling panel.

Time frame: Baseline and week 3

Change in odour severity after bacterial transplantation

Odour evaluation by a trained smelling panel.

Time frame: Baseline and week 4

Change in molecular characterisation of the bacterial community.

Data from ClinicalTrials.gov

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Secondary Outcomes

Change in odour severity after bacterial transplantation

Odour evaluation by a trained smelling panel.

Time frame: Baseline and 2 months

Change in odour severity after bacterial transplantation

Odour evaluation by a trained smelling panel.

Time frame: Baseline and 4 months

Change in odour severity after bacterial transplantation

Odour evaluation by a trained smelling panel.

Time frame: Baseline and 6 months

Change in molecular characterisation of the bacterial community

Microbial evaluation by means of DNA extraction and Denaturing Gradient Gel Electrophoresis (DGGE).

Time frame: Baseline and 2 months

Change in molecular characterisation of the bacterial community

Microbial evaluation by means of DNA extraction and Denaturing Gradient Gel Electrophoresis (DGGE).

Time frame: Baseline and 4 months

Change in molecular characterisation of the bacterial community

Microbial evaluation by means of DNA extraction and Denaturing Gradient Gel Electrophoresis (DGGE).

Time frame: Baseline and 6 months