Analgesic Effect of Beta 2-mimetics in the Treatment of Neuropathic Pain

Phase 2TerminatedNCT01582646

University Hospital, Strasbourg, France20 enrolled

Overview

Neuropathic pain is due to a lesion or disease affecting the nervous system. Antidepressants (ADs) are recommended as the first line treatment. In a murine model, the investigators evidenced that antidepressants antiallodynic action is mediated through β2-adrenergic receptor stimulation and that β-mimetics display the same effect. These data support the idea that β-mimetics could offer a therapeutic alternative to ADs for neuropathic pain treatment. This study will aim at assessing the effects of terbutaline on neuropathic pain symptoms.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Postthoracotomy Pain Postthoracoscopy Neuropathic Pain

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adults from 18 to 75 years old * neuropathic painful condition following a thoracotomy or thoracoscopy for at least 3 months Exclusion criteria: * cardiovascular risk * unstable diabetes mellitus * allergy for terbutaline * hypokaliemia without treatment * untreated hypothyroidism * HIV- or chemotherapy-induced neuropathy * cancer being treated by chemo- or radio-therapy * concomitant treatment with β-blockers, tricyclic ADs or morphine * concomitant pain more severe than neuropathic pain- pregnant women

Locations (2)

CHU de Besançon

Besançon, France

Hôpitaux Universitaires de Strasbourg

Strasbourg, France

Outcomes

Primary Outcomes

Change from baseline in the average intensity of pain during the last 24 hours reported by the patient on a 11 points Numeric Scale

Time frame: Day one, day 14 and day 28 of each 4 weeks period