Exercise in Breast Cancer Survivors

University of Mississippi Medical Center

Overview

The investigators hypothesize that exercise in postmenopausal breast cancer survivors will result in an increase in the plasma concentrations of angiostatic factors and a decrease in the plasma concentrations of angiogenic factors. Exercise is expected to result in a circulating angiostatic phenotype that inhibits adipose tissue mass, growth of breast cancer tumor, growth of microscopic residual disease after breast cancer resection, decreases rates of local-regional recurrence, decreases rates of distant recurrence, and increases survival.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Conditions

Breast Cancer Obesity

Interventions

ExerciseBEHAVIORAL

The participant will exercise for 16 weeks under supervision. The exercise regimen is increased slowly over 16 weeks.

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \> 18 years of age and \< 65 years of age * Female * BMI \> 25 * Weight \< 350 pounds * English as a primary language * Postmenopausal * Invasive ER-positive cancer on biopsy and subsequent definitive surgical therapy * Received and Completed standard of care adjuvant therapy (Concurrent endocrine therapy acceptable) * 6-12 months after completion of therapy (excluding adjuvant endocrine therapy) at time of randomization Exclusion Criteria: * Recurrent breast cancer * DCIS only (no invasive component) * Taking a Beta Blocker or Verapamil * Pregnant * Wheelchair bound * Unable to ambulate independently * Concurrent uncontrolled medical or psychiatric disorder * Open wound * Stage IV breast cancer * Progression of disease * Bilateral mastectomies

Locations (1)

University of Mississippi Health Care

Jackson, Mississippi, United States

Outcomes

Primary Outcomes

Number of participants that complete the study as a measure of feasibility of an exercise intervention in obese breast cancer survivors.

Number of participants that enroll in the study and actually complete the study

Time frame: 12 months

Secondary Outcomes

IGF-1, endostatin, and VEGF levels in obese breast cancer survivors undergoing an exercise intervention as a measure of angiostatic phenotype:

IFG-1 levels,unbound VEGF levels, Endostatin levels

Time frame: 12 months

Amount of adipose tissue mass as measured on CT scans in obese breast cancer survivors before and after exercise intervention as a measure of weight loss

Adipose tissue mass volume as measured on CT scan

Time frame: 12 months

Data from ClinicalTrials.gov

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