Convective therapies have been proposed for improving chronic dialysis patient outcomes, including intradialytic symptomatic hypotension. To evaluate the frequency of sessions with intradialytic symptomatic hypotension in different types and doses of convective therapies compared with low-flux hemodialysis (HD), the investigators performed a multicentre, open-label, randomized controlled trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
146
Online pre-dilution hemofiltration was performed with a synthetic high-flux membrane and an infusate/blood flow ratio of one
Online pre-dilution hemodiafiltration was performed with a synthetic high-flux membrane with an infusate/blood flow ratio of 0.6 and a dialysate plus infusate rate of 700 ml/min.
Ospedale S.Marta S.Venera
Acireale (CT), Italy
Intradialytic symptomatic hypotension
Intradialytic symptomatic hypotension was defined as a rapid symptomatic fall of the systolic blood pressure by at least 30 mmHg or that required nursing and/or medical intervention
Time frame: all dialysis sessions, three per week, for 2 years
Resistance to erythropoiesis-stimulating agents
Resistance to erythropoiesis-stimulating agents was measured as (EPO therapy in IU/week)/(Hb in g/dL\*body wheight in kg)
Time frame: Monthly for 2 years
Calcium-phosphate metabolism
Outcome measures: phosphatemia, calcemia and PTH
Time frame: Monthly for 2 years
Beta2 microglobulin
Time frame: Every six months for 2 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Ospedale F. Miulli
Acquaviva delle Fonti, Italy
Ospedale Civile
Alghero, Italy
Ospedale regionale di Aosta
Aosta, Italy
Ospedale degli Infermi
Biella, Italy
Ospedale SS. Trinità ASL 8
Cagliari, Italy
S. Michele Hospital
Cagliari, Italy
Ospedale Civile "P. Merlo"
La Maddalena, Italy
Alessandro Manzoni Hospital
Lecco, Italy
Ospedale "C. POMA"
Mantova, Italy
...and 17 more locations