The Mochudi Prevention Project ART Protocol

Inclusion Criteria: * HIV-1 infection * CD4 cell count ≥ 250 cells/mm3 * HIV-1 RNA ≥ 50,000 cp/mL * No AIDS-defining illness or other illness that would cause volunteer to be eligible for ART through the Botswana National Program (these volunteers should be referred to the National Program for treatment) * Age 16 to 64 years * Botswana citizen * Resident of the north-east segment of Mochudi * The following laboratory values obtained within 60 days prior to study enrollment: * Absolute neutrophil count (ANC) ≥ 500 cells/mm3. * Hemoglobin ≥ 7.0 g/dL. * AST (SGOT), ALT (SGPT), and bilirubin ≤ 5 X ULN. Note: if the estimated creatinine clearance (by Cockgroft-Gault equation) is \<60 mL/min, then TDF/FTC will be substituted with ZDV/3TC * Ability to swallow oral medications. * Ability and willingness of participant to give informed consent (or in case of participants \< 18 years of age, ability and willingness to provide assent; and for parent/guardian to provide consent). * Not currently involuntarily incarcerated. * Karnofsky performance score ≥ 70 at time of study enrollment. * If participating in sexual activity that could lead to pregnancy and of reproductive potential, female participants must use two reliable methods of contraception simultaneously, one of which must be a barrier method, while receiving protocol-specified medications, and for 12 weeks after stopping the medications. * For participants \< 18 years of age: Weight of 40kg or more Exclusion Criteria: * Receipt at any time prior to study enrollment of \> 7 days cumulative treatment with any ARV or combination of ARVs (except ARVs taken for any length of time during pregnancy for the prevention of mother-to-child transmission (pMTCT) or ARVs taken for occupational exposure). * Current receipt of 3-drug ART for pMTCT * Allergy/sensitivity to any study drug or its formulations. * Acute therapy for serious medical illnesses, in the opinion of the site investigator, within 14 days prior to enrollment.