Antihypertensive Effect and Safety of Peptides Derived From Coldwater Shrimp

Inclusion Criteria: * mild or moderate hypertension (systolic blood pressure 130 - 160 mmHg and diastolic blood pressure ≤ 100 mmHg) * age 30 - 75 years * body weight ≥ 60 kg * stable body weight * use of effective contraception in women of childbearing potential Exclusion Criteria: * body mass index ≥ 35 * antihypertensive drug treatment, regular high dose NSAID treatment and the use of cyclosporine or tacrolimus * diabetes (type 1 and 2) * anemia, abnormal electrolytes, proteinuria, abnormal liver, kidney and thyroid function, clinically significant biochemistry, any other clinically significant hematology and/or biochemistry at the investigator's discretion * cardiovascular disease (myocardial infarction, unstable angina pectoris, coronary artery bypass graft, percutaneous transluminal coronary angioplasty, temporal ischemic attack within six months prior to screening) including stroke and congestive heart failure * secondary hypertension history of cancer or malignant disease within the past five years * any metabolic disease, gastrointestinal disorder or other clinically significant disease/disorder which in the investigator's opinion could interfere with the results of the study or the safety of the subjects * fish and other seafood allergies, citrus allergy, multiple food allergies * alcohol abuse * smokers and tobacco/snuff/nicotine users * consumption of food supplements targeted to blood pressure lowering within 30 days before randomization * pregnant and lactating mothers, women, planning for pregnancy during the study * participation in clinical trials 30 days prior to this study and participation in other clinical intervention