The purpose of this study is to determine the pharmacokinetics of laropiprant following administration of a single dose of 1 (Panel A) and 2 (Panel B) combination tablets of MK-0524A in adolescents with heterozygous familial hypercholesterolemia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
10
Plasma Area Under the Concentration Curve From 0 to Infinity (AUC0-∞) of Laropiprant
Time frame: Predose Day 1 up to 24 hours postdose
Plasma Maximum Concentration (Cmax) of Laropiprant
Time frame: Predose on Day 1 up to 48 hours postdose
Total Urinary Excretion of Niacin and Niacin Metabolites
Time frame: Predose on Day 1 up to 72 hours postdose
Plasma Cmax of Nicotinuric Acid (NUA)
Time frame: Predose on Day 1 up to 48 hours postdose
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