Ezetimibe has become the treatment choice for patients with sitosterolemia. Ezetimibe is an inhibitor of cholesterol absorption from the gastrointestinal tract. The purpose of this study is to determine if ezetimibe improves whole body plant sterol and cholesterol homeostasis.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
8
10mg ezetimibe/day, at least 4 months
Richardson Centre for Functional Foods and Nutraceuticals
Winnipeg, Manitoba, Canada
Plasma cholesterol level
Plasma cholesterol level will be assessed by GC
Time frame: 8 months
Plasma sitosterol level
Plasma plant sterol assessment using GC
Time frame: 8 months
Cholesterol absorption
Use stable isotope technique to assess cholesterol absorption
Time frame: 4 month
Cholesterol synthesis
Use of stable isotope to assess cholesterol synthesis.
Time frame: 4 months
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