The Effects of Dexmedetomidine and Tracheal Intubation on Heart Rate Variability and QTc Interval

Yonsei University80 enrolled

Overview

The purpose of this study is to investigate effect of dexmedetomidine and tracheal intubation on heart rate variability and QTc interval.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Anesthesia, General

Interventions

0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 minDRUG

ECG monitoring for evaluation of QTc interval

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient who are regarded as ASA class I * age 20 to 60 * patient scheduled for Intubation for surgery Exclusion Criteria: * QTc interval \> 440 ms * arrythmia * Patient who is taking a medicine which effects QTc interval * HTN * DM * renal disease * hepatic disease * pregnant * illiterate

Locations (1)

Severance hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Change of QTc interval

T1- baseline, T2- to evaluate the effect of dexmedetomidine on QTc interval, T3- to evaluate QTc interval just before intubation, T4,5,6 - to evaluate QTc interval after intubation

Time frame: T1 (at rest), T2 (5 min after dexmedetomidine infusion), T3 (just before intubation), T4(1 min after intubation), T5(2 min after intubation), T6(3min after intubation)

Data from ClinicalTrials.gov

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