Safety and Immunogenicity of the Live Oral Cholera Vaccine Candidate PXVX0200

Inclusion Criteria: * Healthy Men or women, age 18 to 50 years (inclusive) without significant medical history, physical or clinical lab abnormalities (as per protocol defined ranges) * Women of childbearing potential must have negative urine pregnancy test and must be willing to use adequate birth control for 2 months following vaccination and have additional pregnancy tests as indicated * Vaccinees must live alone or have no more than two household contacts willing to sign informed consent and participate in the study * Household contacts must be healthy (based on medical history) men or women aged 18-65 years (inclusive) Exclusion Criteria: * Healthcare workers who have direct contact with patients who are immunodeficient, are HIV-positive, have unstable medical condition or are under the age of 18 * Childcare workers who have direct contact with children who are 2 years of age or younger or those employed in the food service industry * Resides with HHCs who are under the age of 18 or over the age of 65 * Has abnormal stool pattern defined as fewer than 3 stools per week or more than 2 stools per day in past 6 months * Has known allergy to, or known medical condition that precludes the use of both tetracycline or ciprofloxacin * Previously received a licensed or investigational cholera vaccine * Has history of cholera or enterotoxigenic E. coli infection (natural infection or experimental challenge) * Travel to a cholera-endemic area and experienced symptoms consistent with traveler's diarrhea in the previous 5 years * Received or plans to receive any other licensed vaccines from 14 days prior to the study vaccination until Day 28 * Received or plans to receive antibiotics (other than protocol-specified) or chloroquine within 14 days prior to the study vaccination through to Day 28