Studying Genes in Samples From Younger Patients With Rhabdomyosarcoma

Children's Oncology Group58 enrolled

Overview

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and find biomarkers related to cancer. It may also help doctors find better ways to treat cancer. PURPOSE: This research trial studies genes in samples from younger patients with rhabdomyosarcoma.

OBJECTIVES: * To obtain a larger cohort of rhabdomyosarcoma samples (alveolar and embryonal) to establish a more accurate estimate of the frequency of particular genetic lesions. * To provide the statistical power to establish an unambiguous connection between focal genetic lesions, histological subtype, and outcome for patients with rhabdomyosarcoma. OUTLINE: DNA samples are analyzed in solid and liquid phase for exons of all genes mutated from previous discovery. DNA is then eluted and sequenced by illumina platform.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sarcoma

Interventions

mutation analysisGENETIC

nucleic acid sequencingGENETIC

laboratory biomarker analysisOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Matched genomic deoxyribonucleic acid (DNA) from tumor and germline samples from patients diagnosed with rhabdomyosarcoma (alveolar or embryonal) PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Frequency of particular genetic lesions

Identification of mutations that occur in at least 5% of rhabdomyosarcomas as a whole

Data from ClinicalTrials.gov

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