Studying Gene Expression and Location in Samples From Patients With Brain Tumors

Children's Oncology Group10 enrolled

Overview

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to brain tumors. PURPOSE: This research studies gene expression and location in samples from patients with brain tumors.

OBJECTIVES: * To determine the expression and subcellular localization of nei endonuclease VIII-like 3 (NEIL3) in brain tumors. OUTLINE: Tissue microarray samples are analyzed for NEIL3 expression and subcellular localization by immunohistochemical methods.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Brain and Central Nervous System Tumors

Interventions

gene expression analysisGENETIC

genetic linkage analysisGENETIC

microarray analysisGENETIC

immunohistochemistry staining methodOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Tissue microarrays (TMA) samples from the Biopathology Core * Samples from patients diagnosed with brain tumors * Progenitor, or blast, cell origin PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Correlation of NEIL3 expression and/or nuclear localization with tumor type or grade with respect to degree of differentiation

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.