RBC Transfusion in Severe Anemia With Lactic Acidosis

Massachusetts General Hospital290 enrolled

Overview

The hypothesis of this study is that prolonged-storage RBCs are not inferior to short-storage RBCs for the time required to clear elevated blood lactate levels in children with severe anemia.

This study will measure the time to resolution of lactic acidosis in patients with severe anemia following blood transfusion.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

290

Conditions

Anemia

Interventions

RBC transfusionBIOLOGICAL

RBC transfusion of different storage age

Eligibility

Sex: ALLMin age: 6 MonthsMax age: 5 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 6 mos to 5 years * Hg \< 5 g/dL and Lactate \> 5 mM Exclusion Criteria: * Receiving transfusion other than RBCs * Children with known or suspected cardiac disease

Locations (1)

Mulago Hospital

Kampala, Uganda

Outcomes

Primary Outcomes

Reduction of elevated levels of blood lactate during 24 following RBC transfusion

Time frame: 24 hours

Secondary Outcomes

Normalization of vital signs

Time frame: 24 hours

Correction of acidosis

Time frame: 24 hours

Data from ClinicalTrials.gov

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