CURE Addiction Center of Excellence: Brain Mechanisms of Relapse and Recovery

Inclusion Criteria: 1. Sign an informed consent form; 2. Be between the ages of 18 and 60; 3. Have a diagnosis of opioid dependence according to DSM IV-TR criteria (as assessed by the MINI); 4. Be in good general health as determined by complete physical examination and laboratory tests; 5. Have a negative result for urinary opioids and must self report being at least 3 days opioid free. Participants may have a diagnosis of alcohol dependence so long as they do not have severe alcohol dependence that requires medical supervision for alcohol withdrawal. Exclusion Criteria: 1. Current severe alcohol dependence that requires medical supervision for alcohol withdrawal; 2. Current psychosis, dementia, mental retardation, or history of schizophrenia; 3. Significant clinical abnormalities in hematology, chemistry, or urinalysis; 4. Significant clinical cardiovascular, neurological, hepatic, renal, pulmonary, metabolic, endocrine, or gastrointestinal disorders; 5. Female subjects who are pregnant or lactating, or female subjects of childbearing potential who are not using birth control (oral contraceptives, barrier (diaphragm or condom) plus spermicide, or levonorgestrel implant); (Pregnancy testing will be done on all females of child bearing age); and 6. Current diagnosis of chronic pain disorder.