Casinomacropeptide and Satiety

University of California, Davis20 enrolled

Overview

Assessing 5 different milk derived proteins versus placebo for appetite regulation and satiety, delivered via shake vehicle.

Assessing 5 different milk derived proteins versus placebo for appetite regulation and satiety, delivered via shake vehicle. Subjects will attend a 5 hour post-prandial study day. Subjects will keep food records 1 and 3 days prior to study visit, day of visit, and day after visit; food to be weighed using study provided dietary scale.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Lack of Satiety Excess Intake of Macronutrients Appetite Disorders

Interventions

WheyOTHER

Preload containing complete whey protein.

Whey-CMPOTHER

Preload containing complete whey protein which is missing the CMP/GMP portion of the protein.

ControlOTHER

Preload control matched for energy to the other 5 preloads.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * Unrestrained (score ≤ 10 on the Eating Inventory (EI) questionnaire, Stunkard and Messick 1985) * Women * 18 years of age * Consume a low/moderate protein diet (12-20% protein energy). * Meet BMI criteria of 19 to 24 kg/m2 OR 29 to 34 kg/m2, inclusive. Exclusion Criteria: * Women who score ≥ 10 on the Beck Depression Inventory (BDI, Beck and Beamesdorfer 1974) * Women who score ≥ 30 on Eating Attitudes Test (EAT, Garner and Garfinkel 1979), * Have current or past (previous 1 year) medical conditions that may interfere with any of the outcomes of this study. * Weigh less than 110 lbs * Are currently or have been modifying diet or exercise patterns to gain or lose weight in previous 60 days * Have unstable body weight (fluctuations of ≥ 5 kg in 60 day period) * Are excessive exercisers or trained athletes * Taking any medications that would affect appetite or any other study-described endpoint will also be excluded. * Allergies or intolerances to foods consumed in the study. * Smoker * Pregnant/lactation

Locations (1)

University of California, Davis (Ragle Human Nutrition Research Center)

Davis, California, United States

Outcomes

Primary Outcomes

Post-prandial satiety

Blood biochemical markers of appetite regulation.

Time frame: 6 hours

Post-prandial satiety

Assessing biobehavioral aspects of appetite regulation through VAS.

Time frame: 6 hours

Secondary Outcomes

Extended satiety

Utilizing self reported food intake, looking for changes associated with the different proetin compositions of the shakes.

Time frame: 48 hours

Data from ClinicalTrials.gov

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