Collagenase Option for Reduction of Dupuytren's Contracture in Japan

Inclusion Criteria: * At least 20 years old when written informed consent is obtained. * Having a diagnosis of Dupuytren's contracture and flexion contracture due to palpable cord in at least 1 non-thumb finger (20° to 100° in MP joint and 20° to 80° in PIP joint). * Positive tabletop test result (i.e., cannot simultaneously place affected finger and palm on a table). * Voluntary written informed consent is obtained. Exclusion Criteria: Patients meeting any of the following criteria will be excluded: * Is pregnant, may be pregnant, wishes to become or could become pregnant during the study (i.e., unless acceptable contraception is used, the patient has been sterilized, or the patient is postmenopausal \[no menstrual period for at least 12 months without any other medical cause\]), or is breastfeeding. * Has a coexisting chronic disease of the hand that could impact assessment (muscular disease, neurological disease, neuromuscular disease). * Has received another investigational product 30 or fewer days before first injection of the investigational product. * Has undergone aponeurectomy, aponeurotomy, needle aponeurotomy/fasciotomy, verapamil/interferon injection, or another Dupuytren's Contracture treatment of the primary joint 90 or fewer days before first injection of the investigational product. * Is allergic to collagenase or any of the excipients of AK160. * Has taken tetracycline derivative such as minocycline and doxycycline 14 or fewer days before first injection of the investigational product. * Has received a collagenase product 30 or fewer days before first injection of the investigational product. * Is currently taking or has taken, 7 or fewer days before first injection of the investigational product, an anticoagulant or antiplatelet drug (other than ≤150 mg/day of aspirin). * Has suffered a recent stroke, hemorrhage, or other disease affecting the hands. * Has a serious disease unsuited for the study. * Receiving treatment for a malignancy. * History of drug or alcohol addiction within the past 5 years or history of drug or alcohol abuse within the past year. * Has received previously the investigational product (AK160, AA4500, XIAFLEX®, or XIAPEX®). * Otherwise found ineligible as a subject by the investigator.