Renal Denervation in Diabetic Nephropathy

Inclusion Criteria: * Type 2 diabetes mellitus male or female patient * Individual is \> 18 and ≤ 75 years old * Diabetic nephropathy (if no pathological examination, diagnosis based on the association of history of diabetes, diabetic retinopathy and no hematuria) * Proteinuria/creatininuria ratio \> 0.1 g/mmol lasting for 8 weeks * Under stable medication regimen including for at least 2 months full tolerated doses of al least 1 RAAS blocker (ACEI, renin inhibitor, ARB) and a diuretic * 2 functional kidneys sizing ≥ 90 mm; eGFR \> 20 mL/min/1.73m² (MDRD formula * Suitable aorto-renal vascular anatomy compatible with the endovascular denervation procedure; Informed consent has been signed * Health insurance policy active Exclusion Criteria: * Patients with an estimated glomerular filtration rate (eGFR) of less than 20 mL/min/1.73 m2 * Patients unable to sign an informed consent, to understand the protocol, living too far from the specialized center * Non-diabetic renal disease * Patients with severe hypertension (grade 3 ESH classification) * Kaliemia ≥ 6mmol/L * History of nephrogenic fibrosis-induced MRI contrast media * Patient with single functioning kidney * Patient with contrast media allergy * Patient with any implantable device incompatible with low frequency waves delivery * Patient with contra-indication to the anti-proteinuric standardized medication regimen * Patient with transient or fixed cerebral ischemia within 3 months before inclusion * Patient with myocardial infarction, unstable angina pectoris, coronary bypass or percutaneous angioplasty within 3 months before inclusion * Patient with asthma or chronic obstructive pulmonary disease with a contra-indication to beta-blockers medication * Patient with type 1 diabetes mellitus * Uncontrolled type 2 diabetes mellitus (Hb1Ac \> 10%) * Patient with malignancy within the 5 past years * Patient with any medical or surgical condition that could worsen the risk of the study, according to the investigator; Patient with chronic alcohol consumption * Patient with atrial fibrillation and/or a brachial circumference of ≥ 42cm * Patient is pregnant, nursing or planning to be pregnant