Immobilization and Protein Supplementation (IM-PRO)

Maastricht University Medical Center35 enrolled

Overview

In the present study, the effects of 5 days of lower limb immobilization with or without twice-daily protein supplementation on muscle mass and muscle fiber characteristics will be determined. A young group will be included to compare the changes in muscle mass and muscle fiber characteristics between young and old men.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Disuse Atrophy Aging

Interventions

ImmobilizationBEHAVIORAL

Immobilization with protein (elderlY), immobilization without protein (elderly and young)

Eligibility

Sex: MALEMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male * Aged from 18-35 years and from 65-75 years * 18.5 \< BMI \< 30 kg/m2 Exclusion Criteria: * Smoking * Performing regular resistance training in the previous 6 months * Hypertension (according to WHO criteria) \[52\] and/or cardiovascular disease * Any back/leg/knee/shoulder complaints which may interfere with the use of crutches * Systemic use of antibiotics within 3 weeks prior to the study visit * Current systemic use of corticosteroids, growth hormone, testosterone, immunosuppressants or insulin * Type 2 diabetes mellitus * Any history of thrombosis * Any family history (1st grade) of thrombosis * All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis). * Myocardial infarction within the last 3 years * Use of anti-coagulants * Any (history of) gastrointestinal disease that interferes with GI function * Indications related to interaction with the study product: * Known allergy to milk or milk products * Known galactosemia

Locations (1)

Maastricht University Medical Centre

Maastricht, Netherlands

Outcomes

Primary Outcomes

Change in muscle mass

Time frame: three days before immobilization, and directly after immobilization (day of cast removal; day 6)

Change in muscle fiber size

Time frame: three days before immobilization, and directly after immobilization (day of cast removal; day 6)

Secondary Outcomes

Change in muscle strength measured by quadriceps 1-Repetition Maximum by Leg Extension

Time frame: Three days before immobilization, and directly after immobilization (day of cast removal; day 6)

Data from ClinicalTrials.gov

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