Effect of Early Management on PAin and DEpression in Patients With PancreatoBiliary Cancer, EPADE-PB

Inclusion Criteria: * Ages Eligible for Study: 18 Years and older Genders Eligible for Study: Both Accepts Healthy Volunteers: No * Pathologic confirmed locally advanced or metastatic pancreatic cancer or biliary tract cancer * within 8 weeks after diagnosis * cancer-related pain (Brief Pain Inventory \[BPI\] worst pain score \>3), depression (Center for Epidemiological Studies-Depression Scale \[CES-D\] \>16) or both * Karnofsky Performance Rating Scale ≥50% Exclusion Criteria: * Opioid intolerance * History of drug or alcohol abuse * Impaired sensory or cognitive function * Pregnant or lactating woman * Women of child bearing potential not using a contraceptive method * Sexually active fertile men not using effective birth control during medication of study drug and up to 6 months after completion of study drug if their partners are women of child-bearing potential