Considering the widespread use of sodium fluoride (NaF) and monofluorophosphate (MFP) based toothpastes, the present study aim to evaluate F availability in saliva after use of the top-selling Brazilian toothpastes. In a blind, crossover clinical trial study, volunteers will brush their teeth with one of the following toothpastes: 1) non-fluoride toothpaste (negative control group); 2) NaF/silica based toothpaste 3)MFP/calcium carbonate based toothpaste. After brushing, a rinse with purified water will be performed. Unstimulated saliva will be collected before and up to 60 min after brushing. Ionic fluoride and total soluble fluoride (corresponding to the sum of fluoride as ion and as MFP) will be determined after acid treatment of salivary samples to hydrolyze MFP. Fluoride will be determined using an ion selective electrode.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
12
1-min brushing with 1 g of the assigned toothpaste followed by a 10 mL purified water rinse
Piracicaba Dental School, University of Campinas
Piracicaba, São Paulo, Brazil
Area under the curve of salivary fluoride concentration versus time after brushing with fluoride toothpastes
Time frame: 60 minutes
Percentage of MFP hydrolyzed in saliva as a function of time
Time frame: 60 minutes
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