The Relation Between Uric Acid Level and Endothelial Dysfunction in Patients With Polycystic Kidney Disease

TC Erciyes University150 enrolled

Overview

There are substantial data demonstrating increased endothelial dysfunction, inflammation and oxidative stress in patients with Autosomal dominant polycystic kidney disease (ADPKD), the association between serum uric acid level and endothelial dysfunction has not been elucidated yet in these patients. Therefore, in this study, the investigators aimed to examine the relationship between the uric acid level and the ED in normotensive ADPKD patients with preserved renal function.

This is the first study to evaluate the relationship between uric acid and endothelial dysfunction in patients with early stage ADPKD

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Polycystic Kidney, Autosomal Dominant

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ADPKD patients with normal renal function, * Normotensive ADPKD patients Exclusion Criteria: * Patients with impaired kidney function, * Atherosclerotic disorders, * Diagnosis of hypertension, gout, diabetes, * Using of insulin, thiazide, allopurinol or uricosuric drugs

Locations (1)

Erciyes University Medical School

Kayseri, Turkey (Türkiye)

Outcomes

Primary Outcomes

Measurement of asymmetric dimethylarginine (ADMA) and flow mediated dilatation (FMD)

ADMA,FMD and uric acid measurements were performed to determine endothelial dysfunction in ADPKD patients

Time frame: 4 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.