Anemia of inflammation (AI), a normochromic, normocytic anemia, associated with abnormal iron utilization, erythropoietin hyporesponsiveness, and decreased red blood cells (RBC) survival is a very common problem in hospitalized patients for acute inflammatory diseases and develops within few days from the onset of illness. Deleterious effects of anemia include increased risk of cardiac related morbidity and mortality in critically ill and older patients. Anemia is mediated by hepcidin, the 25-amino acid polypeptide hormone that is central to iron trafficking. Several studies have been performed on pathophysiology of AI in patients affected by chronic diseases but few explore iron metabolism in humans with acute inflammation. The aim is to develop effective new strategies to detect and manage AI in the setting of acutely ill patients, based on the understanding of iron balance underlying this disorder.
Study Type
OBSERVATIONAL
Enrollment
100
Internal Medicine Department - U.O. Medicina Interna 1/A
Via Francesco Sforza 35, Milan, Italy
RECRUITINGimpact of acute inflammatory state on hemoglobin levels
Hemoglobin levels, Blood Red Cells markers, C-RP and other routinary inflammatory markers on day 1 and day 6 (or 8), IL-1, IL-4, IL-6, IL-10, alpha-TNF, gamma-IFN, GDF-15, erythropoietin and hepcidin on day 1 and on day 6 (or 8)
Time frame: 6 days - 8 days
impact of acute inflammatory cytokines on hepcidin-driven iron balance and monocytes role in anemia of acute inflammation
serum iron levels, ferritin and transferrin saturation, circulating monocytes and their HAMP mRNA.
Time frame: 6 days - 8 days
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