Evaluation of the Effect of Saffron (Crocus Sativus) on Pain Control After Root Canal Therapy in Teeth With Vital Pulps

Zahedan University of Medical Sciences36 enrolled

Overview

The purpose of this study is to determine whether saffron is effective in the pain control after root canal therapy in vital teeth.

Among patients refer to endodontics department of Zahedan Faculty of Dentistry whom with moderate to severe pain in a single canal tooth will be selected and randomly divided in 2 groups of saffron and placebo. After root canal therapy each patient in each group will receive a box of 8 similar capsules. They will use 1 capsule exactly after treatment completion and then each 6 hours up to 48 hours. Patients will record their pain intensity in each time period according to Visual Analog Scale(VAS)and finally mean pain intensity will be compared between 2 groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Post-treatment Pain Following Root Canal Therapy

Interventions

starchOTHER

100 mg in each capsule every 6 hours up to 48 hours (400 mg/day)

saffronOTHER

100 mg in each capsule every 6 hours up to 48 hours (400 mg/day)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients who have at least one vital tooth with one root canal and moderate to severe pain Exclusion Criteria: 1. teeth with periapical lesions 2. patients with history of: * allergy to saffron * diabetes mellitus * cardiovascular disorders * kidney and liver diseases * blood and hormonal disorders * electrolyte imbalance 3. women in pregnancy or breast feeding period and 4. use of analgesics or opioids during 4 hours before treatment

Locations (1)

Zahedan university of medical sciences, Vice-chancellor for research

Zahedan, Iran

Outcomes

Primary Outcomes

change in VAS score

Patients will record their pain intensity in each time period according to Visual Analog Scale (VAS)

Time frame: Every 6 hours after treatment completion up to 48 hours

Data from ClinicalTrials.gov

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